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Prof.  John  Nolan  Howard Chair in Human Nutrition, Fulbright Scholar, European Research Council (ERC) Fellow

School/Department
School of Science, Chemical And Life Sciences
Telephone
+353 51834074
Email:
JMNOLAN@wit.ie
Campus:
Carriganore
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My Biography

Prof. John Nolan is the Principal Investigator of the Macular Pigment Research Group (MPRG, www.mprg.ie). His research group studies the role of eye nutrition for vision and prevention of blindness, and current studies are investigating the link between nutrition and brain health and function.

Professor Nolan has successfully supervised eleven students to MSc, PhD and MD level, and is currently supervising six PhD candidates as part of ongoing projects at the MPRG. He has presented at over 70 international scientific conferences and has published over 70 peer-reviewed scientific papers on his area of research (1731 = citations, H index = 25). Professor Nolan is also Chair of the International Macular Carotenoids Conference, which is held at Downing College, Cambridge University, UK., see www.macularcarotenoids.org

Publications
Title Author(s) Volume/Pages Date
Re: lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controlled study: the importance of supplementing with all three macular carotenoids. Nolan J, Beatty S, Dennison J 29/1072 July,2013
Response to Bernstein et al. Nolan JM, Meagher K, Kashani S, Beatty S / December,2013
Macular pigment and its contribution to vision Loskutova E, Nolan J, Howard A, Beatty S 5/1962-9 May,2013
Visual outcome after antioxidant supplementation Beatty S, Nolan JM, Muldrew KA, Woodside J, Stevenson MR, Chakravarthy U 120/645 March,2013
What is meso-zeaxanthin, and where does it come from? Nolan JM, Meagher K, Kashani S, Beatty S 27/899-905 August,2013
Investigation of genetic variation in scavenger receptor class B, member 1 (SCARB1) and association with serum carotenoids McKay GJ, Loane E, Nolan JM, Patterson CC, Meyers KJ, Mares JA, Yonova-Doing E, Hammond CJ, Beatty S, Silvestri G 120/1632-40 August,2013
Visual performance in patients with neovascular age-related macular degeneration undergoing treatment with intravitreal ranibizumab Sabour-Pickett S, Loughman J, Nolan JM, Stack J, Pesudovs K, Meagher KA, Beatty S / January,2013
The natural history of tractional cystoid macular edema Charalampidou S, Nolan J, Beatty S 32/2045-51 November,2012
Estimation of effective lens position using a method independent of preoperative keratometry readings Dooley I, Charalampidou S, Nolan J, Loughman J, Molloy L, Beatty S 37/506-12 March,2011
The respective relationships between lipoprotein profile, macular pigment optical density, and serum concentrations of lutein and zeaxanthin Loane E, Nolan JM, Beatty S 51/5897-905 November,2010
A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration Nolan JM, Loughman J, Beatty S 56/270-286 February ,2012
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment Akkali MC, Loughman J, Howard AN, Beatty S 101/9-15 August ,2012
Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxanthin: Letter Beatty S 53/6303-6304 September ,2012
Education is positively associated with macular pigment: the Irish Longitudinal Study on Ageing (TILDA) Feeney J, Kenny RA, Cronin H, O'Regan C, Savva GM, Loughman J, Finucane C, Connolly E, Meagher K, Beatty S 53/7855-7861 November ,2012
Impact of dietary carotenoid deprivation on macular pigment and serum concentrations of lutein and zeaxanthin Nolan JM, Beatty S 108/2102-2103 December ,2012
The impact of macular pigment augmentation on visual performance using different carotenoid formulations Nolan JM, Howard AN, Connolly E, Meagher K, Beatty S 53/7871-7880 November ,2012
An evaluation of a novel instrument for measuring macular pigment optical density: the MPS 9000 Scanlon G, Nolan JM, O'Dwyer V, Beatty S 90/e90-7 November,2011
The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study Liew SH, Van Kuijk FJ, Beatty S, Nolan JM, Spector TD, Gilbert CE 53/4963-4968 July ,2012
Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, Stevenson MR Epub ahead of print/ December ,2012
The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS Loughman J, Akkali MC, Stack J, Scanlon G, Davison P, Beatty S 51/459-469 March ,2011
The association between macular pigment optical density and CFH, ARMS2, C2/BF, and C3 genotype Nolan JM, McKay GJ, Beatty S 93/592-598 November ,2011
Changes in macular pigment optical density and serum concentrations of lutein and zeaxanthin in response to weight loss Beatty S, Stack J, Harrison M, Greene I, McBrinn S, Carroll P, Nolan JM 105/1036-1046 April ,2011
Macular pigment: its associations with color discrimination and matching Akkali M, Loughman J, Scanlon G, Nolan J, Beatty S 88/816-822 July ,2011
Supplementation with all three macular carotenoids: response, stability, and safety Beatty S, Loughman J, Howard AN, Louw MS, Nolan JM 52/9207-9217 November ,2011
Prognostic indicators and outcome measures for surgical removal of symptomatic nonadvanced cataract Loughman J, Nolan J, Stack J, Cassidy L, Pesudovs K, Beatty S 129/1155-1161 September ,2011
Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract Nolan J, Loughman J, Stack J, Higgins G, Cassidy L, Beatty S 25/1147-1154 September ,2011
Visual perceptions induced by intravitreous injections of therapeutic agents Nolan J, Ormonde GO, Beatty S 25/494-501 April ,2011
26th Hohenheim consensus conference, September 11, 2010 scientific substantiation of health claims: evidence-based nutrition Aggett PJ, Anton R, Bernstein PS, Blumberg J, Heaney RP, Henry J, Nolan JM, Richardson DP, van Ommen B, Witkamp RF, Rijkers GT, Zöllner I 27/ October,2011
Update on modifiable risk factors for age-related macular degeneration O'Regan S, O'Regan G, Beatty S 11/143-150 November ,2010
Macular pigment optical density in an ageing Irish population: The Irish Longitudinal Study on Ageing Kenny R, O'Regan C, Cronin H, Loughman J, Connolly EE, Kearney P, Loane E, Beatty S 44/131-139 June ,2010
The relationship between macular pigment and visual performance Akkali MC, Beatty S, Scanlon G, Davison PA, O'Dwyer V, Cantwell T, Major P, Stack J, Nolan JM 50/1249-1256 June ,2010
Macular pigment and its contribution to visual performance and experience Davison P.A, Nolan JM, Akkali M.C, Beatty S 3/73-89 March ,2010
Apolipoprotein E genotype is associated with macular pigment optical density McKay GJ, Nolan JM, Beatty S 51/2636-2643 May ,2010
A central dip in the macular pigment spatial profile is associated with age and smoking Beatty S, Loane E, Akkali MC, Connolly EE, Stack J, Nolan JM 51/6722-6728 December ,2010
Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study Beatty S, Thurnham DI, Loughman J, Howard AN, Stack J, Nolan JM 35/335-351 April ,2010
Effect on refractive outcomes after cataract surgery of intraocular lens constant personalization using the Haigis formula Cassidy L, Ng E, Loughman J, Nolan J, Stack J, Beatty S 36/1081-1089 July ,2010
Augmentation of macular pigment following implantation of blue light-filtering intraocular lenses at the time of cataract surgery O'Reilly P, Loughman J, Stack J, Loane E, Connolly E, Beatty S 50/4777-4785 October ,2009
Psychophysical function in age-related maculopathy Nolan J, Chakravarthy U, Beatty S 54/167-210 March ,2009
Foveal anatomic associations with the secondary peak and the slope of the macular pigment spatial profile Galea M, Loane E, Stack J, Beatty S, Nolan JM 50/1383-1391 March ,2009
Risk factors for age-related maculopathy Keane PA, O'Neill EC, Altaie RW, Loane E, Neelam K, Nolan JM, Beatty S / September ,2009
The utility of using customized heterochromatic flicker photometry (cHFP) to measure macular pigment in patients with age-related macular degeneration Hammond BR, Nolan JM, Wooten BR, Mammen A, Smollon W, Snodderly DM 87/445-453 November ,2008
Diet and risk factors for age-related maculopathy Nolan JM, Stack J, Greenberg D, Kyle J, Maddock L, Beatty S 87/712-722 March ,2008
Spatial profile of macular pigment and its relationship to foveal architecture Stringham JM, Beatty S, Snodderly DM 49/2134-2142 May ,2008
Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, Beatty S 53/68-81 February ,2008
The rationale and evidence base for a protective role of macular pigment in age-related maculopathy Kelliher C, Beatty S, Nolan JM 92/1163-1168 September ,2008
Macular pigment and age-related macular degeneration: longitudinal data and better techniques of measurement are needed van Kuijk FJ, Chakravarthy U 49/843-845 March ,2008
Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study Beatty S, Nolan JM, Hense HW, Heimes B, Austermann U, Fobker M, Pauleikhoff D 84/718-728 April ,2007
The relationships between macular pigment optical density and its constituent carotenoids in diet and serum Stack J, O'Connell E, Beatty S 48/571-582 February ,2007
Risk factors for age-related maculopathy are associated with a relative lack of macular pigment Stack J, O' Donovan O, Loane E, Beatty S 84/61-74 January,2007
Measurement of macular pigment optical density using two different heterochromatic flicker photometers Stack J, Beatty S, Nolan JM 32/555-564 June ,2007
Macular carotenoids and age-related maculopathy Neelam K, Nolan J, Au Eong KG, Beatty S 35/821-830 November ,2006
Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin Stack J, Mellerio J, Godhinio M, O'Donovan O, Neelam K, Beatty S 31/199-213 February ,2006
Macular pigment and ocular biometry Nolan J, Loane E, Stack J, O'Donovan O, Au Eong KG, Beatty S 46/2149-2156 June ,2006
Macular pigment levels following successful macular hole surgery O'Gorman N, Nolan J, O'Donovan O, Au Eong KG, Beatty S 89/1105-1108 September ,2005
Measurement of macular pigment: Raman spectroscopy versus heterochromatic flicker photometry O'Gorman N, Nolan J, O'Donovan O, Wong HB, Au Eong KG, Beatty S 46/1023-1032 March ,2005
A novel index for predicting intraocular pressure reduction following cataract surgery Pacheco J, Mahmood U, Nolan J, Beatty S 89/543-546 May ,2005
Macular pigment and percentage of body fat O'Donovan O, Kavanagh H, Stack J, Harrison M, Muldoon A, Mellerio J, Beatty S 45/3940-3950 November ,2004
Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin Nolan J, Kavanagh H, O'Donovan O 430/70-76 October,2004
Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population Murray IJ, Henson DB, Carden D, Koh H, Boulton ME 42/439–446 February ,2001
The role of oxidative stress in the pathogenesis of age-related macular degeneration Koh H, Phil M, Henson D, Boulton M 45/115-134 October,2000
Macular pigment optical density measurement: a novel compact instrument Koh HH, Carden D, Murray IJ 20/105-111 March ,2000
Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland Au Eong KG, McLeod D, Bishop PN 83/1103-1104 October,1999
Macular pigment and age related macular degeneration Boulton M, Henson D, Koh HH, Murray IJ 83/867-877 July,1999
My Research
My Research Group : Macular Pigment Research Group ►

Scientific Skills

  • Epidemiology research

  • Heterochromatic flicker photometry

  • Macular pigment measurement (Maculux, Spectralis)

  • Raman spectroscopy

  • Fundus photography

  • High performance liquid chromatography

  • Analytical techniques in biochemistry

  • Microbiology techniques

  • Statistics

Computer skills

  • SPSS

  • Microsoft Office

  • SigmaPlot

  • MGI PhotoSuite

  • ChemWindows

  • ChemStation

  • Project Manager

Teaching Experience

Lecturer at the Waterford Institute of Technology, the Royal College of Surgeons in Ireland, and the Institute of Eye Surgery, Whitfield Clinic on the following areas:

  • Research methods

  • Quantitative methods

  • Qualitative methods

  • Statistics with SPSS

  • Scientific poster design and presentation

  • Scientific writing and dissemination methods

  • Scientific oral presentation tuition

  • Research skills for clinicians-in-training: 1 day intensive course

  • Interactive Statistics Workshop: 1 day intensive course

  • Nutrition and visual performance

  • Nutrition and age-related macular degeneration (AMD)

Previous teaching experience:

  • Part-time Lecturer and Laboratory Demonstrator, Waterford Institute of Technology: Coordination of 2nd year Microbiology Labs

  • Assessment of undergraduate laboratory work at 2nd year level

  • Supervision of undergraduate project work at diploma and degree level

  • Supervised chemistry and biology practical’s for Waterford Institute’s “Science for Kids Scheme”

My Professional Experience

Education

  • 2002: Bachelor of Science (BSc) in Applied Biology with Quality Management [Honours Degree, Merit Grade 1]

  • 2005: Degree of Doctor of Philosophy (PhD): Determinants of macular pigment in healthy subjects

Academic Achievements

  • Adjunct Professor status awarded by Trinity College Dublin, Ireland, in 2013, in recognition and support of on-going academic collaboration with the TCD-based TILDA study, The Irish LongituDinal Study on Ageing

  • European Research Council Starter Grant awarded in July 2011

  • Howard Fellowship for Science, May 2010, awarded by the Howard Foundation, Cambridge University, UK

  • Royal Academy of Medicine, Section of Ophthalmology: Prize for best paper delivered in 2007. Risk factors for age-related maculopathy: a review of the epidemiologic studies

  • Irish/American Fulbright Scholarship for Science, 2005-2006. Project title: Spatial profile of macular pigment and its relationship with foveal architecture

  • Barbara Knox Gold Medal for best paper, Annual Congress of the Irish College of Ophthalmologists, 2003. Paper title: Macular pigment optical density and serum levels of lutein and zeaxanthin in healthy subjects

  • Best paper runner up at the BioNet Annual Conference, Galway-Mayo Institute of Technology, 2003. Paper title: Macular pigment optical density, serum and dietary lutein and zeaxanthin, in healthy subjects with and without a family history of age-related maculopathy

My Journal