Macular Pigment Research Group

The mission of the Macular Pigment Research Group is to study the role of eye nutrition for vision and prevention of blindness.

The Macular Pigment Research Group (MPRG) is based in Carriganore House, Waterford Institute of Technology, Waterford, Ireland. This unique research facility offers state-of-the-art vision testing laboratories and infrastructure. In addition, we have a high quality biochemical laboratory, which allows us to conduct clinical trials to the highest possible standard.

The focus of our research concerns naturally occurring plant pigments known as carotenoids. Carotenoids play important roles throughout the body, but three particular carotenoids (lutein, zeaxanthin and meso-zeaxanthin) are found at the back of the eye (the macula) where they are collectively known as macular pigment.

The Central Retinal Enrichment Supplementation Trials (CREST) is funded by the European Research Council, and comprises two different trials: CREST Normal and CREST AMD. CREST aims to assess the impact of enriched macular pigment with all three macular carotenoids - lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) - on visual performance and blindness. Of note, this is the first study to test the effects of supplementation with all three macular carotenoids, including MZ, in the context of a sufficiently powered, double-blind, randomized, placebo-controlled clinical trial.

Volunteers Required! Trial 1: CREST Normal

We are looking for volunteers for CREST Normal. This study is investigating ways in which enrichment of macular pigment with the macular carotenoids (lutein, zeaxanthin and meso-zeaxanthin) impact on the visual performance and experience of normal subjects. We aim to recruit 120 subjects in each group. The MPRG investigator affiliated with this trial is PhD student Jessica Dennison.

The following people are suitable to volunteer for CREST Normal:

  • People over the age of 18

  • People with no eye conditions (spectacles and contact lens-wearers can volunteer)

  • People who are not currently taking eye-related dietary supplements (i.e. those containing lutein, zeaxanthin and/or meso-zeaxanthin)

People with diabetes or who have had laser eye surgery are not suitable for this study.

Please call Niamh Owens on 051 302810 or email niamh@ivr.ie


Volunteers Required! Trial 2: CREST AMD

We are looking for volunteers for CREST AMD. This study is investigating ways in which enrichment of macular pigment with the macular carotenoids (lutein, zeaxanthin and meso-zeaxanthin) impacts on the visual performance and experience of subjects with early stage age-related macular degeneration (AMD). The MPRG investigator affiliated with this trial is PhD student Kwadwo Akuffo.

All participants on the CREST AMD study will be guaranteed to receive a supplement containing one of two different formulations of the macular carotenoids lutein, zeaxanthin, and meso-zeaxanthin, as well as a multivitamin. This follows the National Eye Institute standard of care guidelines for patients with AMD.

The following people are suitable to volunteer for CREST AMD:

  • People over the age of 18

  • People who have been diagnosed with early-stage age-related macular degeneration (AMD) in one eye

  • People who are not currently taking eye-dietary supplements (i.e. those containing lutein, zeaxanthin and/or meso-zeaxanthin)

People with diabetes are not suitable for this study.

Please call Sarah O'Regan on 051 845505 or email info@mprg.ie


Document

Links

Egg Xanthophyll Interventional Trial (EXIT: Eggs for Eyes)

The objective of EXIT is the development of a macular carotenoid-enriched egg as an innovative supplement for vision and cognitive health.


Update, December 2013:

The EXIT clinical trial has now been completed, and we sincerely thank all volunteers for their time. Data analysis and publications are now underway.


What is the EXIT Study?
The “EXIT” study aims to improve vision using a novel nutrient-enriched hen egg as a healthy alternative to a normal eye supplement.

What was involved?
A healthy egg-based breakfast was specially prepared by the chefs of the Culinary Arts Department in the WIT Tourism & Leisure Building. Each volunteer was invited to enjoy this breakfast five days a week for eight weeks.

Each volunteers was also asked to attend two study visits; one at the beginning and one at the end of the eight week study. These study visits were held at the Vision Research Centre in Carriganore House, WIT West Campus, and measured visual performance, cognitive function and health checks (including blood pressure and cholesterol) using gold-standard specialised techniques.

Document

Links

Meso-Zeaxanthin Ocular Supplementation Trials (MOST) is an initial investigation into the efficacy of supplementation with meso-zeaxanthin, the central macular carotenoid, for patients with, or at risk of developing, AMD. These studies are comparing different formulations of macular carotenoid supplements and their impact on macular pigment enrichment, visual performance, and disease progression.

Update, December 2013:

All MOST study visits have now been completed, and we sincerely thank all our volunteers who gave us their time for this study over the last three years. Data analysis and publications are now underway.

Links

Prof. John Nolan

Fulbright Scholar, Howard Fellow

John Nolan

Professor John Nolan is the Principal Investigator of the Macular Pigment Research Group, Waterford Institute of Technology, Ireland. His research group studies the role of eye nutrition for vision and prevention of blindness. He has secured ~€4 million in research funding to date to support these studies, and he is currently managing the European Research Council (ERC) funded project entitled Central Retinal Enrichment Supplementation Trials (CREST).

Professor Nolan has successfully supervised 10 students to MSc and PhD level qualifications. His multidisciplinary research team is now the largest group studying the macular carotenoids in the world. He has presented at over 60 international scientific conferences and has published 55 peer-reviewed scientific papers on the topic.

Professor Nolan is Chair of the international Macular Carotenoids Conference. He was awarded Adjunct Professor title from Trinity College Dublin in February 2013 following his leading role in the vision strand of The Irish LongituDinal Study on Ageing (TILDA).

View WIT Profile

Prof. Stephen Beatty

L.R.C.P.I., L.R.C.S.I., M.B., B.Ch., B.A.O.(N.U.I.), M.M.Sc., F.R.C.Ophth, E.B.O.D., M.D. - Director

Stephen Beatty

Professor Stephen Beatty is the Director of the Macular Pigment Research Group. He graduated from the Royal College of Surgeons in Ireland in 1990, and trained as an ophthalmic surgeon in Dublin, Manchester, Birmingham, London and Geneva. He has been a Consultant Ophthalmic Surgeon with a special interest in retinal disease since 2001.

Stephen Beatty has a strong track record in research, with over 100 peer-reviewed publications (2,332 citations, H index 22), and his research interest include cataract and age-related macular degeneration. Stephen Beatty was appointed Professor at Waterford Institute of Technology in 2010 and Adjunct Professor at Trinity College Dublin in 2011.

Dr. David Kelly

PhD - Postdoctoral Senior Scientist

David Kelly

David Kelly is the Postdoctoral Senior Scientist at the Macular Pigment Research Group. David received a BSc (Honours) Degree in Applied Biosciences from Cork Institute of Technology (CIT) in 2006 and was subsequently awarded an Irish Research Council Science, Engineering and Technology (IRCSET) grant to pursue a research PhD at the department of Biological Sciences at CIT. This project focused on the isolation and exploitation of bacteriophages (naturally-occurring bacterial viruses) for the bio-control of both food spoilage bacteria (Lactic acid bacteria) and medical pathogens such as Methicillin Resistant Staphylococcus aureus (MRSA).

After completion of his PhD, David worked in a dual research / technical role in the same department at CIT for three years, gaining experience in many areas such as Microbiology, Biochemistry, Cell Culture, Molecular Biology, Bioinformatics, Biomedical Science, and Food Science. He has also gained previous industrial research and development experience with Glanbia Nutritionals, in addition to Microbiologist roles in the food and beverage industry (Glenpatrick Water, Kilkenny Nutritionals).

He worked as a postdoctoral researcher with Shannon ABC at I.T. Tralee prior to joining the MPRG, using immune and epithelial cell models to investigate the potential of marine extracts for use as novel therapeutic agents against animal parasites.

Ms. Sarah O'Regan

Research Assistant

Sarah O Regan

Sarah O'Regan is the Research Assistant of the Macular Pigment Research Group. She is responsible for patient recruitment and support, budget management and the overall smooth running of the European Research Council-funded Central Retinal Enrichment Supplementation Trials (CREST) research project. Sarah has worked in an administrative and managerial role within the field of prevention of age-related blindness for five years.

View WIT Profile

Ms. Katie Meagher

- Postgraduate Research Student

Katie Meagher

Katie Meagher is a postgraduate research student with the Macular Pigment Research Group. She completed a BSc (Honors) degree in Chemistry and Quality Management at the Waterford Institute of Technology and was recognised with the “Third Level Education Award: Highest Results in final year Chemistry” by the Institute of Chemistry, Dublin, Ireland in 2010. Katie has studied with the Macular Pigment Research Group as a serum carotenoid analyst for over a year and has presented her work at two international conferences. Katie was awarded joint-first place for the Howard Best Poster Award at the first ever Macular Carotenoids & AMD Conference 2011 for her poster entitled "Optimisation and Development for Quantification of Meso-zeaxanthin Method".

Ms. Jessica Dennison

- Postgraduate Research Student

Jessica Dennison

Jessica Dennison is a postgraduate research student with the Macular Pigment Research Group, currently working on the European Research Council-funded Central Retinal Enrichment Supplementation Trials (CREST). She completed her BA in Natural Sciences at Fordham University in New York City. She has done research at the New York Eye & Ear Infirmary with Dr. Dan-Ning Hu on reactive oxygen species damage to human retinal pigment epithelial cells, and protection by melatonin and other antioxidants. She presented her work at the Eastern College Science Conference in 2011. She is also an associate member of Sigma Xi, the Scientific Research Society.

Mr. Kwadwo Owusu Akuffo

O.D. - Postgraduate Research Student

Kwadwo Owusu Akuffo

Kwadwo O. Akuffo is a postgraduate research student with the Macular Pigment Research Group, Waterford Institute of Technology, Ireland. He is currently working on the project entitled “Enrichment of Macular Pigment and its Impact on Vision and Blindness: Central Retinal Enrichment Supplementation Trials (CREST)”

He has been trained in retinal photograph grading at the Reading Centre, Moorfields Eye Hospital, London, UK. With this training, he has completed grading of approximately 10,000 retinal photographs taken as part of The Irish Longitudinal Study on Ageing (TILDA) for AMD, glaucoma and diabetic retinopathy. He is also a member of the TILDA Vision Group.

Kwadwo is an Optometrist by profession. Prior to starting his studies, he worked as a Teaching and Research Assistant at the Department of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.  From 2005 to 2011, he studied Doctor of Optometry (OD) at KNUST, graduating with distinction. During his studies at KNUST, he was on the Faculty of Biosciences Dean’s Honours List on three consecutive occasions for outstanding academic performance. In his final year at KNUST, he was appointed as the President of the Dr. D.B. Kumah Research Group, Department of Optometry and Visual Science, KNUST, during which he coordinated the activities of his colleagues working on various projects in vision science.

Kwadwo is a member of the Association for Research in Vision and Ophthalmology (ARVO), European Academy of Optometry and Optics (EAOO) and the Society for Clinical Trials (SCT). His research interests include age-related eye disease, vision and nutrition.

Ms. Kate Loskutova

- Visiting Medical Research Student

Kate Loskutova

Kate Loskutova is a visiting research student with the Macular Pigment Research Group. She is currently a student at the Moscow State Medical Stomatological University and is anticipated to graduate in 2014, with the Bachelor of General Medicine degree. Kate completed a three week observership at the Basel Augenspital, Switzerland, and a six week observership at the Ophthalmology Department in Glostrup Hospital, Copenhagen, Denmark. She has previously studied the link between antioxidants and age-related macular degeneration with the MPRG in 2010 and is a co-author of the poster entitled "High Serum Concentrations of Lutein are Associated with Elevated 8-oxo-dg in Serum of Normal Subjects" presented at the ARVO 2011 Conference.

Ms. Clare Kirwan

FAOI - Clinical Optometrist

Clare Kirwan

Clare is an optometrist with a First Class Honours Diploma in Optometry from the Dublin Institute of Technology. She won the Harte Barry Prize from the Optician’s Board and the Association of Optometrists Prize on graduation. After many years in retail optometry, Clare joined the Institute of Eye Surgery in 2011, where she works as a clinical optometrist with Professor Stephen Beatty in the Whitfield Clinic, Waterford. In January 2013 she joined the Institute of Vision Research team where she is in charge of the Whitfield Clinic arm of an international research project into the safety and efficacy of Lucentis, a drug used to treat age-related macular degeneration, and to investigate the Health-Related Quality of Life of patients undergoing this treatment. She also manages the Microperimetry Clinic in the Institute of Eye Surgery. Clare is also currently studying for a Masters in Cataract and Refractive Laser Surgery through the University of Ulster, Coleraine.

Ms. Rachel Moran

BSc (Honours) - Postgraduate Research Student

Rachel Moran

Rachel Moran is a postgraduate research student with the Macular Pigment Research Group in Waterford Institute of Technology. She is currently working on a project entitled “Plasma antioxidant status in Irish Adults: The Irish LongituDinal Study on Aging (TILDA)”, a position she successfully attained through competitive interview. She completed a BSc (Honours) degree in Applied Biology with Quality Management in Waterford Institute of Technology and was recognised as AIB Student of the Year in 2011. Rachel has assisted research on the GMSAFOOD project entitled: “Biomarkers for post market monitoring of short and long-term effects of genetically modified organisms on animal and human health” and worked independently, while under the supervision of two experienced researchers, on a research project entitled: “Isolation and characterisation of endospore-forming bacteria isolated from pig manure-derived compost”. She has also gained industry experience as quality assurance administrator in Genzyme.

  • Macular Pigment Research Group Overview 2012
  • An Taoiseach, Mr Enda Kenny TD Launches MPRG Vision Research Centre at WIT
  • MPRG Biochemical Laboratory
  • Macular Pigment Research Group, Vision Research Centre
  • Macular pigment and its functions
  • RTE Nationwide (Ireland)- Dr. John Nolan and Prof. Stephen Beatty
  • Part 1 of RTE Nationwide Programme on Macular Pigment Research Group
  • Part 2 of RTE Nationwide Programme on Macular Pigment Research Group

Irish Research Council (IRC) Postgraduate scheme 2014/2015

The Macular Pigment Research Group (MPRG) is based in Carriganore House, Waterford Institute of Technology, Waterford, Ireland. 

Our mission is to study the role of eye nutrition for vision and cognitive function.

Our unique research facility offers state-of-the-art vision testing laboratories and infrastructure. In addition, we have a high quality biochemical laboratory, which allows us to conduct clinical trials to the highest possible standard.

The focus of our research concerns naturally occurring plant pigments known as carotenoids. Carotenoids play important roles throughout the body, but three particular carotenoids (lutein, zeaxanthin and meso-zeaxanthin) are found at the back of the eye (the macula) where they are collectively known as macular pigment. These carotenoids play an important role in protecting the eye from age-related macular degeneration (AMD), which is the leading cause of blindness in the western world. Please visit our website: www.mprg.ie for more information about our group and projects.

The MPRG welcomes applications from high-achieving academic students who are interested in applying for funding to pursue a research PhD or Masters through the Irish Research Council (IRC) Postgraduate scheme 2014/ 2015. Applications are made online through the following link http://www.research.ie/scheme/government-ireland-postgraduate-scholarship-scheme-20142015. €16,000 is available to successful students as a tax free maintenance grant (1 years funding for Masters and 3 years for PhD). Other support is also provided including: fees, consumables, travel etc. 

Please note that the application closing date for the full proposal is January 28th 2014. 

However, in order to assess the suitability of applications, we request that applicants send application forms, which are available online at the above link (with as much detail as possible completed) to the MPRG before January 4th 2014.

Please note also for students in 4th year of a degree course, that the IRC takes their 3rd year results into consideration (a high 2.1 or 1.1 is desirable); however they want to see evidence of high achievement from first year onwards.

Interested students should send forms and a CV to Dr. David Kelly at the MPRG. dpkelly@wit.ie  051-845525 or 051-845505

    Article     Author(s)     Journal     Year
Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials. Akuffo KO1, Beatty S, Stack J, Dennison J, O'Regan S, Meagher KA, Peto T, Nolan J. Ophthalmic Epidemiol 2014
Concordance of macular pigment measurements obtained using customized heterochromatic flicker photometry, dual-wavelength autofluorescence, and single-wavelength reflectance Dennison JL, Stack J, Beatty S, Nolan JM Exp Eye Res 2013
Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults Feeney J, Finucane C, Savva GM, Cronin H, Beatty S, Nolan JM, Kenny RA Neurobiol Aging 2013
Macular pigment and its contribution to vision Loskutova E, Nolan J, Howard A, Beatty S Nutrients 2013
Visual outcome after antioxidant supplementation Beatty S, Nolan JM, Muldrew KA, Woodside J, Stevenson MR, Chakravarthy U Ophthalmology 2013
Re: lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controlled study: the importance of supplementing with all three macular carotenoids. Nolan J, Beatty S, Dennison J Nutrition 2013
Visual performance in patients with neovascular age-related macular degeneration undergoing treatment with intravitreal ranibizumab Sabour-Pickett S, Loughman J, Nolan JM, Stack J, Pesudovs K, Meagher KA, Beatty S J Ophthalmol 2013
Response to Bernstein et al. Nolan JM, Meagher K, Kashani S, Beatty S Eye (Lond) 2013
What is meso-zeaxanthin, and where does it come from? Nolan JM, Meagher K, Kashani S, Beatty S Eye (Lond) 2013
Investigation of genetic variation in scavenger receptor class B, member 1 (SCARB1) and association with serum carotenoids McKay GJ, Loane E, Nolan JM, Patterson CC, Meyers KJ, Mares JA, Yonova-Doing E, Hammond CJ, Beatty S, Silvestri G Ophthalmology 2013
Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxanthin: Letter Nolan J, Beatty S Invest Ophthalmol Vis Sci 2012
The natural history of tractional cystoid macular edema Charalampidou S, Nolan J, Beatty S Retina 2012
Education is positively associated with macular pigment: the Irish Longitudinal Study on Ageing (TILDA) Nolan JM, Feeney J, Kenny RA, Cronin H, O'Regan C, Savva GM, Loughman J, Finucane C, Connolly E, Meagher K, Beatty S Invest Ophthalmol Vis Sci 2012
The impact of macular pigment augmentation on visual performance using different carotenoid formulations Loughman J, Nolan JM, Howard AN, Connolly E, Meagher K, Beatty S Invest Ophthalmol Vis Sci 2012
A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration Sabour-Pickett S, Nolan JM, Loughman J, Beatty S Mol Nutr Food Res 2012
The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study Hammond CJ, Liew SH, Van Kuijk FJ, Beatty S, Nolan JM, Spector TD, Gilbert CE Invest Ophthalmol Vis Sci 2012
Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM Br J Nutr 2012
Impact of dietary carotenoid deprivation on macular pigment and serum concentrations of lutein and zeaxanthin Loughman J, Nolan JM, Beatty S Br J Nutr 2012
Secondary outcomes in a clinical trial of carotenoids with coantioxidants versus placebo in early age-related macular degeneration Beatty S, Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, Stevenson MR Ophthalmology 2012
Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment Nolan JM, Akkali MC, Loughman J, Howard AN, Beatty S Exp Eye Res 2012
Prognostic indicators and outcome measures for surgical removal of symptomatic nonadvanced cataract Charalampidou S, Loughman J, Nolan J, Stack J, Cassidy L, Pesudovs K, Beatty S Arch Ophthalmol 2011
26th Hohenheim consensus conference, September 11, 2010 scientific substantiation of health claims: evidence-based nutrition Biesalski HK, Aggett PJ, Anton R, Bernstein PS, Blumberg J, Heaney RP, Henry J, Nolan JM, Richardson DP, van Ommen B, Witkamp RF, Rijkers GT, Zöllner I Nutrition 2011
An evaluation of a novel instrument for measuring macular pigment optical density: the MPS 9000 Loughman J, Scanlon G, Nolan JM, O'Dwyer V, Beatty S Acta Ophthalmol 2011
The association between macular pigment optical density and CFH, ARMS2, C2/BF, and C3 genotype Loane E, Nolan JM, McKay GJ, Beatty S Exp Eye Res 2011
Supplementation with all three macular carotenoids: response, stability, and safety Connolly EE, Beatty S, Loughman J, Howard AN, Louw MS, Nolan JM Invest Ophthalmol Vis Sci 2011
Estimation of effective lens position using a method independent of preoperative keratometry readings Dooley I, Charalampidou S, Nolan J, Loughman J, Molloy L, Beatty S J Cataract Refract Surg 2011
Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract Charalampidou S, Nolan J, Loughman J, Stack J, Higgins G, Cassidy L, Beatty S Eye (Lond) 2011
The impact of macular pigment augmentation on visual performance in normal subjects: COMPASS Nolan JM, Loughman J, Akkali MC, Stack J, Scanlon G, Davison P, Beatty S Vision Res 2011
Macular pigment: its associations with color discrimination and matching Davison P, Akkali M, Loughman J, Scanlon G, Nolan J, Beatty S Optom Vis Sci 2011
Changes in macular pigment optical density and serum concentrations of lutein and zeaxanthin in response to weight loss Kirby ML, Beatty S, Stack J, Harrison M, Greene I, McBrinn S, Carroll P, Nolan JM Br J Nutr 2011
Visual perceptions induced by intravitreous injections of therapeutic agents Charalampidou S, Nolan J, Ormonde GO, Beatty S Eye (Lond) 2011
The respective relationships between lipoprotein profile, macular pigment optical density, and serum concentrations of lutein and zeaxanthin Loane E, Nolan JM, Beatty S Invest Ophthalmol Vis Sci 2010
Update on modifiable risk factors for age-related macular degeneration Nolan JM, O'Regan S, O'Regan G, Beatty S Optometry in Practice 2010
Macular pigment optical density in an ageing Irish population: The Irish Longitudinal Study on Ageing Nolan JM, Kenny R, O'Regan C, Cronin H, Loughman J, Connolly EE, Kearney P, Loane E, Beatty S Ophthalmic Res 2010
The relationship between macular pigment and visual performance Loughman J, Akkali MC, Beatty S, Scanlon G, Davison PA, O'Dwyer V, Cantwell T, Major P, Stack J, Nolan JM Vision Res 2010
Effect on refractive outcomes after cataract surgery of intraocular lens constant personalization using the Haigis formula Charalampidou S, Cassidy L, Ng E, Loughman J, Nolan J, Stack J, Beatty S J Cataract Refract Surg 2010
Apolipoprotein E genotype is associated with macular pigment optical density Loane E, McKay GJ, Nolan JM, Beatty S Invest Ophthalmol Vis Sci 2010
Macular pigment and its contribution to visual performance and experience Loughman J, Davison P.A, Nolan JM, Akkali M.C, Beatty S J Optom 2010
A central dip in the macular pigment spatial profile is associated with age and smoking Kirby ML, Beatty S, Loane E, Akkali MC, Connolly EE, Stack J, Nolan JM Invest Ophthalmol Vis Sci 2010
Augmentation of macular pigment following supplementation with all three macular carotenoids: an exploratory study Connolly EE, Beatty S, Thurnham DI, Loughman J, Howard AN, Stack J, Nolan JM Curr Eye Res 2010
Augmentation of macular pigment following implantation of blue light-filtering intraocular lenses at the time of cataract surgery Nolan JM, O'Reilly P, Loughman J, Stack J, Loane E, Connolly E, Beatty S Invest Ophthalmol Vis Sci 2009
Risk factors for age-related maculopathy Connell PP, Keane PA, O'Neill EC, Altaie RW, Loane E, Neelam K, Nolan JM, Beatty S J Ophthalmol 2009
Psychophysical function in age-related maculopathy Neelam K, Nolan J, Chakravarthy U, Beatty S Surv Ophthalmol 2009
Foveal anatomic associations with the secondary peak and the slope of the macular pigment spatial profile Kirby ML, Galea M, Loane E, Stack J, Beatty S, Nolan JM Invest Ophthalmol Vis Sci 2009
The utility of using customized heterochromatic flicker photometry (cHFP) to measure macular pigment in patients with age-related macular degeneration Stringham JM, Hammond BR, Nolan JM, Wooten BR, Mammen A, Smollon W, Snodderly DM Exp Eye Res 2008
The rationale and evidence base for a protective role of macular pigment in age-related maculopathy Loane E, Kelliher C, Beatty S, Nolan JM Br J Ophthalmol 2008
Spatial profile of macular pigment and its relationship to foveal architecture Nolan JM, Stringham JM, Beatty S, Snodderly DM Invest Ophthalmol Vis Sci 2008
Diet and risk factors for age-related maculopathy O'Connell ED, Nolan JM, Stack J, Greenberg D, Kyle J, Maddock L, Beatty S Am J Clin Nutr 2008
Macular pigment and age-related macular degeneration: longitudinal data and better techniques of measurement are needed Beatty S, van Kuijk FJ, Chakravarthy U Invest Ophthalmol Vis Sci 2008
Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration Loane E, Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, Beatty S Surv Ophthalmol 2008
Measurement of macular pigment optical density using two different heterochromatic flicker photometers Loane E, Stack J, Beatty S, Nolan JM Curr Eye Res 2007
Risk factors for age-related maculopathy are associated with a relative lack of macular pigment Nolan JM, Stack J, O' Donovan O, Loane E, Beatty S Exp Eye Res 2007
The relationships between macular pigment optical density and its constituent carotenoids in diet and serum Nolan JM, Stack J, O'Connell E, Beatty S Invest Ophthalmol Vis Sci 2007
Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study Trieschmann M, Beatty S, Nolan JM, Hense HW, Heimes B, Austermann U, Fobker M, Pauleikhoff D Exp Eye Res 2007
Macular carotenoids and age-related maculopathy O'Connell E, Neelam K, Nolan J, Au Eong KG, Beatty S Ann Acad Med Singapore 2006
Macular pigment and ocular biometry Neelam K, Nolan J, Loane E, Stack J, O'Donovan O, Au Eong KG, Beatty S Vision Res 2006
Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin Nolan JM, Stack J, Mellerio J, Godhinio M, O'Donovan O, Neelam K, Beatty S Curr Eye Res 2006
Macular pigment levels following successful macular hole surgery Neelam K, O'Gorman N, Nolan J, O'Donovan O, Au Eong KG, Beatty S Br J Ophthalmol 2005
A novel index for predicting intraocular pressure reduction following cataract surgery Issa SA, Pacheco J, Mahmood U, Nolan J, Beatty S Br J Ophthalmol 2005
Measurement of macular pigment: Raman spectroscopy versus heterochromatic flicker photometry Neelam K, O'Gorman N, Nolan J, O'Donovan O, Wong HB, Au Eong KG, Beatty S Invest Ophthalmol Vis Sci 2005
Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin Beatty S, Nolan J, Kavanagh H, O'Donovan O Arch Biochem Biophys 2004
Macular pigment and percentage of body fat Nolan J, O'Donovan O, Kavanagh H, Stack J, Harrison M, Muldoon A, Mellerio J, Beatty S Invest Ophthalmol Vis Sci 2004
Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population Beatty S, Murray IJ, Henson DB, Carden D, Koh H, Boulton ME Invest Ophthalmol Vis Sci 2001
The role of oxidative stress in the pathogenesis of age-related macular degeneration Beatty S, Koh H, Phil M, Henson D, Boulton M Surv Ophthalmol 2000
Macular pigment optical density measurement: a novel compact instrument Beatty S, Koh HH, Carden D, Murray IJ Ophthalmic Physiol Opt 2000
Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland Beatty S, Au Eong KG, McLeod D, Bishop PN Br J Ophthalmol 1999
Macular pigment and age related macular degeneration Beatty S, Boulton M, Henson D, Koh HH, Murray IJ Br J Ophthalmol 1999

Vacancy: Postgraduate Students

The MPRG welcomes applications from high-achieving academic students who are interested in applying for funding ...

New MPRG website!

We are pleased to announce that the new MPRG website (direct link www.mprg.ie) has now ...

Sarah Sabour-Pickett graduates!

The Macular Pigment Research Group is proud to announce that Sarah Sabour-Pickett has successfully passed ...

Contact

Addresss

Macular Pigment Research Group
Vision Research Centre
Carriganore House
Waterford Institute of Technology
West Campus, Carriganore
Waterford, Ireland

Email

info@mprg.ie

Phone

(00353) 051 845505

Social Media

MPRG Facebook Page